CHIMERIC NEWCASTLE DISEASE VIRUSES PRESENTING NON-NATIVE SURFACE PROTEINS AND USES THEREOF

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专利权人:

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

发明人:

ADOLFO GARCIA-SASTRE,PETER PALESE

申请号：

PT12173114

公开号：

PT2529747T

申请日:

2006.12.01

申请国别(地区):

PT

年份:

2018

代理人:

摘要：

The present invention provides chimeric negative-stand RNA viruses that allow a subject, e.g., an avian, to be immunized against two infectious agents by using a single chimeric virus of the invention. In particular, the present invention provides chimeric Newcastle Disease viruses (NDV) engineered to express and incorporate into their virions a fusion protein comprising the ectodomain of a protein of an infectious agent and the transmembrane and cytoplasmic domain of an NDV protein. Such chimeric viruses induce an immune response against NDV and the infectious agent.

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