THE MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY
发明人:
PALESE PETER,GARCIA-SASTRE ADOLFO
申请号：
AP2008004504
公开号：
AP2911A
申请日:
2006.12.01
申请国别(地区):
AP
年份:
2014
代理人:
摘要：
The present invention provides chimeric negative-stand RNA viruses that allow a subject, e.g., an avian, to be immunized against two infectious agents by using a single chimeric virus of the invention. In particular, the present invention provides chimeric Newcastle Disease viruses (NDV) engineered to express and incorporate into their virions a fusion protein comprising the ectodomain of a protein of an infectious agent and the transmembrane and cytoplasmic domain of an NDV protein. Such chimeric viruses induce an immune response against NDV and the infectious agent.
