THE MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNI
发明人:
PALESE, PETER,GARCIA-SASTRE, ADOLFO
申请号：
HK09106837.5
公开号：
HK1127731B
申请日:
2009.07.24
申请国别(地区):
HK
年份:
2013
代理人:
摘要：
The present invention provides chimeric negative-stand RNA viruses that allow a subject, e.g., an avian, to be immunized against two infectious agents by using a single chimeric virus of the invention. In particular, the present invention provides chimeric Newcastle Disease viruses (NDV) engineered to express and incorporate into their virions a fusion protein comprising the ectodomain of a protein of an infectious agent and the transmembrane and cytoplasmic domain of an NDV protein. Such chimeric viruses induce an immune response against NDV and the infectious agent.
