ANDREA RIZZI,GABRIELE AMARI,MATTEO BIAGETTI,IAN LINNEY,FABIO RANCATI
申请号：
ARP120102064
公开号：
AR088023A1
申请日:
2012.06.08
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Compounds that act as antagonists of Muscarinic receptors at the same time as B2 adrenergic receptor agonists, processes for their preparation, compositions containing Same, Therapeutic uses and combinations with other pharmaceutically Active Ingredients. Useful for Asthma, chronic bronchitis or chronic obstructive pulmonary disease (COPD).Claim 1: wherein is a compound of General formula (1), where q is a group selected from the group of formulas (2)； Z is H or Oh； and choose between divalent groups of formula (3) or (4), where a u00b9 a-squared independently and are absent or are selected from The group consisting alquileno c u2081 u208b u2081 u2082,Cicloalquileno c u2083 u208b u2088 and heterocicloalquileno c u2083 u208b u2088 optionally substituted with one or more substituents selected from the group consisting c u2081 u208b u2086 c u2081 u208b u2086 alkyl, arylalkyl and heteroarilalquilo c u2081 u208b u2086； b is absent or is selected from the group which was And in cicloalquileno c u2083 u208b u2088, heterocicloalquileno c u2083 u208b u2088, arylene,Heteroarileno or is a group of formula (5) optionally substituted with one or More groups are selected from Halogen, nitryl, c u2081 u208b u2086 alkoxy alkyl, arylalkyl and c u2081 u208b u2086 c u2081 u208b u2086； c is absent or is selected from the group consisting of - or -, co -, OC (o) -, - C (OO) -, - S -, - (OR) - S, - S (o) u2082 -, - N (r u2077) - N - (CO) r u2077 -, - N (CO) nhr u2077 -, - N - or r u2077 (SO u2082) is one of the remnants of the group of formulas (6),Where r u2077 is H or is selected from the group consisting c u2081 u208b u2088 linear or branched alkyl, cycloalkyl c u2083 u208b u2088, heterocicloalquilo c u2083 u208b u2088 arylalkyl c u2081 u208b u2086, aryl, heteroaryl and c u2081 u208b u2086alquilo c u2081 u208b u2086 alkoxy, and r u2078 is c u2081 u208b u2088carbonilo alkoxy； d is ausent And is selected from the group consisting alquileno c u2081 u208b u2081 u2082, - C (ch u2083) u20
