Л.МОЛЬТЕНИ ЭНД К.ДЕЙ ФРАТЕЛЛИ АЛИТТИ СОЧИЕТА ДИ ЭСЕРЧИЦИО С.П.А. (IT)
发明人:
АНДЖЕЛИ Роберто (IT),РАФФАЭЛИ Уильям (IT),РИГАМОНТИ Мария Адель (IT)
申请号：
RU2012145095/15
公开号：
RU2012145095A
申请日:
2011.03.23
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. Formulations of rapid release in the form of two-layer tablets containing an opioid agonist and an opioid antagonist, in which these active ingredients are kept separated from each other, each of them in one of these two layers. The formulations according to claim 1, wherein the amount of opioid antagonist is 500-4000 times less than the amount of opioid agonist. The formulations according to claims 1 and 2, wherein said opioid antagonists are selected from: oxycodone, hydromorphone, morphine, codeine, buprenorphine, methadone. 4. The formulations according to claims 1 and 2, wherein said opioid agonists are selected from: naltrexone and naloxone. 5. The formulations according to claims 1 and 2, wherein the agonist-containing layer comprises: lactose SD, pregelatinized corn starch, pigment, Macrogol 6000, Cutina® HR, colloidal silicon oxide, magnesium stearate. 6. The formulations according to claim 5, in which the indicated components of the layer containing the opioid agonist are present in the following amounts (in mass%) based on the total weight of the components of the above layer: lactose SD 40-60%, pregelatinized corn starch 10-20% , pigment 0.5-2%, Macrogol 6000 10-20%, Cutina® HR 5-20%, colloidal silicon oxide 0-2%, magnesium stearate 0-2%. 7. The formulations according to claims 1 and 2, in which the layer containing the opioid antagonist includes: Granulak 200 lactose, corn starch, croscarmellose sodium, polyvinylpyrrolidone K30, colloidal silicon oxide, magnesium stearate. 8. The formulations according to claim 7, in which the indicated components of the layer containing the opioid antagonist are present in the following amounts (in mass%) based on the total weight of the components of the above layer: Granulak 200 lactose 30-80%, corn starch 5-10%, croscarmellose sodium 5-10%, polyvinyl1. Рецептуры быстрого выделения в форме двухслойных таблеток, содержащих агонист опиоида и антагонист опиоида, в которых указанные активные ингредиенты сохраняются ра
