螺吲哚酮化合物及其作為治療劑之用途农业专利-农业学术服务平台

发明人:: CHAFEEV, MIKHAIL,麦克海里　乔威夫,麥克海里　喬威夫,CHOWDHURY, SULTAN,苏鲁旦　乔德亨瑞,蘇魯旦　喬德亨瑞,FRASER, ROBERT,罗伯特　法瑟,羅伯特　法瑟,FU, JIANMIN,符江明,KAMBOJ, RAJENDER,雷杰德　坎柏,雷傑德　坎柏,HOU, DUANJIE,胡端吉,LIU, SHIFENG,刘欣方,劉欣方,BAGHERZ,麦克海里乔威夫,麥克海里喬威夫,苏鲁旦乔德亨瑞,蘇魯旦喬德亨瑞,罗伯特法瑟,羅伯特法瑟,雷杰德坎柏,雷傑德坎柏

摘要：: This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R 1 , R 2a , R 2b , R 2c , R 2d , R 3a , R 3b , R 3c , and R 3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof； or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.本發明係針對式(I)螺-吲哚酮化合物：；(I)；其中k,j,Q,R1,R2a,R2b,R2c,R2d,R3a,R3b,R3c及R3d均如本文定義，作為其立體異構物、對掌異構物、互變異構物，或其混合物；或其藥學上可接受之鹽、溶劑合物或前體藥物，其可用於治療及/或預防鈉通道所媒介之疾病或症狀，譬如疼痛。亦揭示包含該化合物之醫藥組合物，及製備與使用該化合物之方法。