Refers to a compound of formula wherein R1 - R2 R1 - Z is H, c1-c4 alkyl, Formilo, acetyl, Benzoyl, trifluoroacetilo R2 is Oh, NH2 Peptide Z is a formula I, in which AIB and x2 X12 is Lys, ARG, LEU, x16 and x17 are X X20 is ARG, ARG, his, X X21 is ASP, glu, ala x24 is x27 is Leu, X X X is ARG X28, X3 is or is absent X X is Glu, Lys, ser, CYS, dBu, DPR, Orn.Said Compound has exactly two lipophilic substituents at each of the positions, 16, 17, 20, 24, 27, 28 or 30 SELECTED dodecanoil - hexadecanoil Gamma Gamma Glu, glu, octadecanoil gamma Glu, among others, being useful in the treatment of weight loss, improve standards of gluc Osa in circulation, reduce levels of LDL in circulationREFERIDA A UN COMPUESTO DE FORMULA R1-Z-R2 DONDE R1 ES H, ALQUILO C1-C4, ACETILO, FORMILO, BENZOILO, TRIFLUOROACETILO R2 ES OH, NH2 Z ES UN PEPTIDO DE FORMULA I, EN LA QUE X2 ES Aib Y Ser X12 ES Lys, Arg, Leu X16 Y X17 SON Arg, X X20 ES Arg, His, X X21 ES Asp, Glu X24 ES Ala, X X27 ES Leu, X X28 ES Arg, X X3 ES X O ESTA AUSENTE X ES Glu, Lys, Ser, Cys, Dbu, Dpr, Orn. DICHO COMPUESTO TIENE EXACTAMENTE 2 SUSTITUYENTES LIPOFILOS, CADA UNO EN UNA DE LAS POSICIONES 16, 17, 20, 24, 27, 28 O 30 SELECCIONADO DE DODECANOIL-GAMMA-GLU, HEXADECANOIL-GAMMA-GLU, OCTADECANOIL-GAMMA-GLU, ENTRE OTROS, SIENDO UTIL EN EL TRATAMIENTO DE PERDIDA DE PESO, MEJORAR LOS NIVELES DE GLUCOSA EN CIRCULACION, REDUCIR LOS NIVELES DE LDL EN CIRCULACION
