SCHAFFER, DAVID V.,KLIMCZAK, RYAN R.,KOERBER, JAMES T.,FLANNERY, JOHN G.,DALKARA MOUROT, DENIZ,VISEL, MEIKE,BYRNE, LEAH C.T.
申请号：
CA2833870
公开号：
CA2833870A1
申请日:
2012.04.20
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
