SCHAFFER, David V.,KLIMCZAK, Ryan R.,KOERBER, James T.,FLANNERY, John G.,DALKARA MOUROT, Deniz,VISEL, Meike,BYRNE, Leah C.T.
申请号：
DK12774323
公开号：
DK2699270T3
申请日:
2012.04.20
申请国别(地区):
DK
年份:
2017
代理人:
摘要：
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
