A kind of isolated human antibody or human antibody segment, it can specifically bind people's delta sample ligand 4 (hD114) and block the combination of hD114 and Notch receptor. The anti-hD114 human antibody or antibody fragment can measure in conjunction with hD114 through Applications of surface plasmon resonance, affinity costant≤500pM.一種分離的人抗體或人抗體片段,它能特異性結合人delta樣配體4(hD114)並阻斷hD114與Notch受體的結合。該抗hD114人抗體或抗體片段能與hD114結合,經表面等離子體共振技術測量,其親和常數≤500pM。