FREESE STEPHEN JOHN,ANDERSON ANNALIESA,PAVLIAK VILIAM,JANSEN KATHRIN UTE,DODGE INGRID LEA,SCOTT TRACY DEE,NANRA JASDEEP SINGH,PRASAD A KRISHNA,GREEN BRUCE ARTHUR
申请号:
IN201718024899
公开号:
IN201718024899A
申请日:
2017.07.13
申请国别(地区):
IN
年份:
2017
代理人:
摘要:
The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1 carboyl di 1,2,4 triazole (CDT) or 3 (2 pyridyldithio) propionyl hydrazide (PDPH).