FREESE, STEPHEN JOHN,ANDERSON, ANNALIESA,PAVLIAK, VILIAM,JANSEN, KATHRIN UTE,DODGE, INGRID LEA,SCOTT, TRACY DEE,NANRA, JASDEEP SINGH,PRASAD, A. KRISHNA,GREEN, BRUCE ARTHUR
申请号：
MYPI 2011006233
公开号：
MY158231A
申请日:
2010.06.22
申请国别(地区):
MY
年份:
2016
代理人:
摘要：
THE PRESENT INVENTION RELATES TO IMMUNOGENIC CONJUGATES COMPRISING S. AUREUS SEROTYPE 5 AND 8 CAPSULAR POLYSACCHARIDES CONJUGATED TO CARRIER PROTEINS AND METHODS FOR THEIR PREPARATION AND USE. METHODS FOR MAKING THE IMMUNOGENIC CONJUGATES OF THE INVENTION INVOLVE COVALENT CONJUGATION OF THE CAPSULAR POLYSACCHARIDES WITH THE CARRIER PROTEINS USING CONJUGATION CHEMISTRY INVOLVING EITHER 1,1-CARBOYL-DI-1,2,4 TRIAZOLE (CDT) OR 3-(2-PYRIDYLDITHIO)-PROPIONYL HYDRAZIDE (PDPH).
