FREESE, STEPHEN, JOHN,ANDERSON, ANNALIESA,PAVLIAK, VILIAM,JANSEN, KATHRIN, UTE,DODGE, INGRID, LEA,SCOTT, TRACY, DEE,NANRA, JASDEEP, SINGH,PRASAD, A., KRISHNA,GREEN, BRUCE, ARTHUR
申请号：
SG2011094968
公开号：
SG177310A1
申请日:
2010.06.22
申请国别(地区):
SG
年份:
2012
代理人:
摘要：
The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1 carboyl di 1,2,4 triazole (CDT) or 3 (2 pyridyldithio) propionyl hydrazide (PDPH).
