Use of the compound of formula (I) and the pharmaceutically acceptableaddition salts thereof for the manufacture of a medicament for topicaltreatment or 5 prevention of acne formula (I) wherein: R representsmethoxymethyl, R1 represents methyl, Rz represents methyl, Y represents thegroup formula (II) The compound of formula (I) and the pharmaceutically acidaddition salts thereof show selective activity against propionibacterium acneand are suitable for use in a method of treament or prevention of acne.