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Antibodies against human PCSK9 for use in Methods of treatment based on individual dosing regimens
专利权人:
SANOFI
发明人:
申请号:
ARP120100274
公开号:
AR084937A1
申请日:
2012.01.27
申请国别(地区):
AR
年份:
2013
代理人:
摘要:
1. Claim 1: a method for dealing with a disease or disease affected by the performance or activity of PCBs, including: treating an antibody or part of its antigen binding; Specifically, hpcsk9 (protein transform ASA subtilisin A / kexina-9 human) was added to a person in need, where antibodies or fragments bound to the same antigen were administered in a dose range of 5 mg to 500 mg. And the subjects were given an inhibitor of reduced HMG-CoAHMG-CoA reducing inhibitor 2: antibody or part of antigen added in it was administered in the dose range of 0.05 mg to 100 mg; Specifically, hpcsk9 (protein transform ASA subtilisina / kexina-9 human) was added to treat the diseases or conditions affected by the performance or activities of PCSK9, When an antibody or part of an antibody is used in doses ranging from 5 mg to 500 mg,(i) In addition to antibodies, antibodies that bind antibodies, or part of them, to antibodies will be used in combination with an HMG-CoA inhibitor that is reduced in a dose range from 0.05 mg to 100 mg. 119. Claim 23, including (a) finished product of packaging material; (b) antibody or binding part of the same antigen specially connected with hpcsk9;The labels or instructions in the Y (c) packaging materials indicate that patients who receive the treatment of this antibody or antigen binding fragment can treat a specific disease or disease composed of high cholesterol, high blood fat, degreasing, etc, Myocardial infarction and cardiovascular disease Claim 36: a method for preventing (persistently) high LDL content from affecting blood, including: treatment of antibodies or parts of antibody binding;Specifically, hpcsk9 (protein transform ASA subtilisin A / kexina-9 human) was added to a person in need, where antibodies or fragments bound to the same antigen were administered in a dose range of 5 mg to 500 mg. The subjects were treated with a reduced HMG-CoA inhibitor in the range of 0.05 mg to 100 mg.Reivindicación 1: Un método para tratar una enfer
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