BECKER, Michael S.,LI-WEBER, Min,KRAMMER, Peter H.
申请号：
EPEP2014/075230
公开号：
WO2015/075165A1
申请日:
2014.11.21
申请国别(地区):
WO
年份:
2015
代理人:
摘要：
The present invention relates to an inhibitor of protein translation for use in high-dose chemotherapy and/or high-dose radiotherapy of disease to an inhibitor of protein translation for use in a combination therapy comprising high-dose chemotherapy and/or high-dose radiotherapy of disease and to an inhibitor of protein translation for use in preventing adverse effects of high-dose chemotherapy and/or high-dose radiotherapy or for preventing radiation syndrome in a subject. Moreover, the present invention relates to a combined preparation for simultaneous, separate or sequential use comprising at least one inhibitor of protein translation or a pharmaceutically acceptable salt thereof and at least one chemotherapeutic agent for use in high- dose chemotherapy of disease to the use of an inhibitor of protein translation in high-dose chemotherapy and/or high-dose radiotherapy of disease and to a medicament for the therapy of disease which contains (i) at least one inhibitor of protein translation or a pharmaceutically acceptable salt thereof, (ii) at least one chemotherapeutic agent, and (iii) at least one pharmaceutically acceptable carrier. Further, the present invention relates to a kit comprising at least one inhibitor of protein translation and instructions on administering high-dose chemotherapy and/or instructions on administering high-dose radiotherapy in the presence of said inhibitor of protein translation as well as to improved methods of preventing in a subject requiring high-dose chemotherapy and/or high-dose radiotherapy adverse events caused by said therapy or therapies, of improving a medical condition requiring high-dose chemotherapy and/or high-dose radiotherapy and of treating a subject in need of high-dose chemotherapy and/or high-dose radiotherapy.La présente invention concerne un inhibiteur de translation de protéine, destiné à être utilisé en chimiothérapie à dose élevée et/ou radiothérapie à dose élevée de maladie un inhibiteur de translation de
