An intravascular device interface and associated systems and methods are disclosed. In some embodiments, the intravascular device interface includes a housing containing one or more processors in communication with a memory, a first connector, and a second connector. The first connector is secured to the housing and configured to interface with a proximal connector of an imaging intravascular device sized and shaped for insertion into human vasculature. The second connector is also secured to the housing and is configured to interface with a proximal connector of a physiology intravascular device. The one or more processors process data received from the first connector or the second connector for transmission over a device output. In some embodiments disclosed herein, an intravascular device interface includes a single connector that may be configured to support a non-rotational imaging device or a rotational imaging device.
