A drape for use with fluorescence-based imaging and white-light imaging includes a drape body. The drape body is configured to limit passage of electromagnetic radiation including light through the drape body to an interior imaging environment defined by the drape body such that electromagnetic radiation including ambient light within the interior imaging environment does not exceed a predetermined threshold. The drape also includes a connecting element permanently coupled to the drape body. The connecting element defines a hole in the drape body. The connecting element is configured to attach the drape to a portable, handheld imaging device.
