Mixed crystalline form-viii of agomelatine, its method of preparation, application and pharmaceutical use

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专利权人:

LES LABORATOIRES SERVIER

发明人:

HUANG YU,ZHU XUEYAN,SHAN HANBIN,YUAN ZHEDONG,YU XIONG,LONG QING

申请号：

NZ61571412

公开号：

NZ615714A

申请日:

2012.03.22

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Provided herein is a mixed crystal agomelatine (Form-VIII), the preparation method and use thereof and a pharmaceutical composition containing the same, wherein the mixed crystal mainly contains an agomelatine crystal form VI. The mixed crystal is stable and has good reproducibility, and is found through a stability test to be superior to a crystal form VI in terms of stability. Therefore, the Form-VIII of agomelatine has an advantage in terms of preparation.

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中国工程科技知识中心

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http://www.ckcest.cn/home/