CONTROL OF PROTEIN GLYCOSYLATION BY CULTURE MEDIUM SUPPLEMENTATION AND CELL CULTURE PROCESS PARAMETERS
- 专利权人:
- BIOGEN IDEC MA INC.
- 发明人:
- YANG, WILLIAM,HUANG, YAO-MING,MCELEARNEY, KYLE,TESCIONE, LIA,LAMBROPOULOS, JAMES,ZHANG, AN,TSANG, VALERIE,RYLL, THOMAS
- 申请号：
- WO2014US51727
- 公开号：
- WO2015026846(A1)
- 申请日:
- 2014.08.19
- 申请国别(地区):
- 世界知识产权组织国际局
- 年份:
- 2015
- 代理人:
- 摘要：
The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
- 来源网站：
- 中国工程科技知识中心
