Jon C. Aster,Stephen C. Blacklow,A. Thomas Look,Adolfo A. Ferrando,Andrew P. Weng
申请号：
US12453833
公开号：
US08716233B2
申请日:
2009.05.22
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increase receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients.
