William Colby Brown,Richard W. Heidebrecht,Jason Brubaker,Christian Fischer,John T. Hendrix,Elizabeth H. Kelley,Rachel N. MacCoss,Joey L. Methot,Thomas Miller,Karin M. Otte,Phieng Siliphaivanh,Thomas
申请号：
US13501628
公开号：
US20130053386A1
申请日:
2010.10.05
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention encompasses a novel class of diaryl ether derivatives which inhibit the processing of APP by the putative γ-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimers disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.
