Richard W. Heidebrecht,Chaomin Li,Benito Munoz,Andrew Rosenau,Laura M. Surdi,Paul Tempest
申请号：
US12989131
公开号：
US08759579B2
申请日:
2009.04.17
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention encompasses a novel class of cyclobutyl sulfone derivatives which inhibit the processing of APP by the putative γ-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimers disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.
