North, Michael Aidan,Wang, Jianying,Wickman, Grant Raymond,Zhang, Jingchuan,Amundson, Karin Kristina,Bedian, Vahe,Belouski, Shelley Sims,Hu-Lowe, Dana Dan,Jiang, Xin,Karlicek, Shannon Marie,Kellermann
申请号：
HK16107449.4
公开号：
HK1219488A
申请日:
2016.06.27
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
The present disclosure relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular doman (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The disclosure also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present disclosure also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The disclosure also relates to transgenic animals or plants comprising nucleic acid molecules of the present disclosure.
