NORTH, MICHAEL AIDAN,WANG, JIANYING,WICKMAN, GRANT RAYMOND,ZHANG, JINGCHUAN,AMUNDSON, KARIN KRISTINA,BEDIAN, VAHE,BELOUSKI, SHELLEY SIMS,HU-LOWE, DANA DAN,JIANG, XIN,KARLICEK, SHANNON MARIE,KELLERMANN
申请号：
PL12152953
公开号：
PL2447283T3
申请日:
2006.09.06
申请国别(地区):
PL
年份:
2015
代理人:
摘要：
The present disclosure relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular doman (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The disclosure also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present disclosure also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The disclosure also relates to transgenic animals or plants comprising nucleic acid molecules of the present disclosure.
