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Ludzkie przeciwciała monoklonalne przeciwko kinazie podobnej do receptora aktywiny-1
专利权人:
Amgen Fremont Inc.;Pfizer Inc.
发明人:
NORTH, MICHAEL AIDAN,WANG, JIANYING,WICKMAN, GRANT RAYMOND,ZHANG, JINGCHUAN,AMUNDSON, KARIN KRISTINA,BEDIAN, VAHE,BELOUSKI, SHELLEY SIMS,HU-LOWE, DANA DAN,JIANG, XIN,KARLICEK, SHANNON MARIE,KELLERMANN
申请号:
PL15169743
公开号:
PL2960253T3
申请日:
2006.09.06
申请国别(地区):
PL
年份:
2018
代理人:
摘要:
The present disclosure relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular doman (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The disclosure also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present disclosure also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The disclosure also relates to transgenic animals or plants comprising nucleic acid molecules of the present disclosure.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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