HUMAN MONOCLONAL ANTIBODIES TO ACTIVIN RECEPTOR-LIKE KINASE-1

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专利权人:

AMGEN FREMONT INC.;PFIZER INC.

发明人:

NORTH, MICHAEL, AIDAN,WANG, JIANYING,WICKMAN, GRANT, RAYMOND,ZHANG, JINGCHUAN,AMUNDSON, KARIN, KRISTINA,BEDIAN, VAHE,BELOUSKI, SHELLEY, SIMS,HU-LOWE, DANA, DAN,JIANG, XIN,KARLICEK, SHANNON, MARIE,KELL

申请号：

MYPI 20080556

公开号：

MY164457A

申请日:

2006.09.06

申请国别(地区):

MY

年份:

2017

代理人:

摘要：

THE PRESENT INVENTION RELATES TO ANTIBODIES INCLUDING HUMAN ANTIBODIES AND ANTIGEN-BINDING PORTIONS THEREOF THAT BIND TO THE EXTRACELLULAR DOMAN (ECD) OF ACTIVIN RECEPTOR-LIKE KINASE-1 (ALK-1) AND THAT FUNCTION TO ABROGATE THE ALK-1/TGF-BETA-1/SMAD 1 SIGNALING PATHWAY. THE INVENTION ALSO RELATES TO HEAVY AND LIGHT CHAIN IMMUNOGLOBULINS DERIVED FROM HUMAN ANTI-ALK-1 ANTIBODIES AND NUCLEIC ACID MOLECULES ENCODING SUCH IMMUNOGLOBULINS. THE PRESENT INVENTION ALSO RELATES TO METHODS OF MAKIND HUMAN ANTI-ALK-1 ANTIBODIES, COMPOSITIONS COMPRISING THESE ANTIBODIES AND METHODS OF USING THE ANTIBODIES AND COMPOSITIONS. THE INVENTION ALSO RELATES TO TRANSGENIC ANIMALS OR PLANTS COMPRISING NUCLEIC ACID MOLECULES OF THE PRESENT INVENTION. FIG. 1

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