FIELD: pharmacology.SUBSTANCE: invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof which have an inhibitory activity against p38 MAP kinase. In formula (I), W is NH, Y is selected from the -O (CR3R4)n- group, where n is 0, R1 is (IIb) group , X1 is -(CH)-, R9 is C1-C6alkyl, C3-C6cycloalkyl or phenyl optionally substituted with halogen atoms, R12 is a hydrogen atom, A is a bivalent cycloalkylene radical having 5, 6 or 7 ring atoms, wherein the said cycloalkylene ring is attached to W and Y and fused to a phenyl ring, wherein such phenyl ring is optionally substituted with one or two R27 groups, R27 is selected from halogen, R2 is a radical of formula (IVb) or (IVc) where R17 is selected from a single electron pair, hydrogen or aryl, where any such aryl may be optionally substituted by a C1-C6alkyl or C3-C7cycloalkyl； or R17th is a group of general formula (V) R20 is selected from the group consisting of -CH3 or -C2H5； R21 is -CH3 or -C2H5； R18 is selected from the group consisting of a single electron pair, hydrogen, aryl, heteroaryl, -(C1-6alkyl), -(C3-C7cycloalkyl), -(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6alkyl) and (C5-C7heterocycloalkyl)-(C3-C6cycloalkyl) group, R19 Is selected from -CF3, z1, z2, z3 and z4 are independently selected from the group consisting of C, N, O, -CH- and -NH- groups, in such combination that the resulting ring is an aromatic system, T is -CR28=； R28 is halogen； R22 is H or halogen. The invention also relates to a pharmaceutical composition comprising the said compounds, a method for treatment of diseases which benefit from p38 MAP kinase inhibition, and their application for manufacture of a medicament for treatment of such diseases.EFFECT: increased efficiency of compounds application.14 cl, 2 tbl, 35 exИзобретение относится к соединениям формулы (I) или их фармацевтически приемлемым солям, которые обладают ингибирующей активностью в отношении МАР-киназы р38. В формуле (I) W предста
