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COMPOSITION, IN STABLE CONDITION, SINGLE-STRANDED NUCLEIC ACID MOLECULE WHICH SUPPRESSES EXPRESSION OF GENE TGF-Β1
专利权人:
发明人:
申请号:
RU2018119672
公开号:
RU2018119672A3
申请日:
申请国别(地区):
RU
年份:
2019
代理人:
摘要:
The present invention provides a composition containing a single-stranded nucleic acid molecule consisting of a nucleotide sequence shown by 5'-AGCAGAGUACACACAGCAUAUACC-P-GGUAUAUGCUGUGUGUACUCUGCUUC-P-G-3' (SEQ ID NO: 1) (in the sequence, P is a proline derivative linker represented by (I) in the DESCRIPTION) and a buffer, and having the following features: (a) being in the form of a solution at ambient temperature; and (b) a content of the nucleic acid molecule after storage at 25°C, relative humidity 60% for 4 weeks, of not less than 80% relative to the content at the time of start of the storage.
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