МИКЛ Тревис (US),ГЮНТЕР Свен (US),МИКЛ Кристэл (US),ЧИ Гочэнь (US),КАНЬСКИ Ярослав (US),МАРТИН Андреа К. (US),БЕРА Бинду (US)
申请号：
RU2012103476/04
公开号：
RU2012103476A
申请日:
2010.07.01
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A composition comprising at least one conjugate, wherein the conjugate comprises hydrocodone and at least one benzoic acid, a derivative thereof, a salt thereof, or a combination thereof. The composition according to claim 1, where at least one benzoic acid or derivative of benzoic acid has the following formula I: where X, Y and Z are independently selected from the group consisting of H, O, S, NH and - (CH) -； R, R and R are independently selected from the group consisting of H, alkyl, alkoxy, aryl, alkenyl, alkynyl, halogen atom, halogen substituted alkyl, alkylaryl, arylalkyl, heterocycle, arylalkoxy, cycloalkyl, cycloalkenyl and cycloalkynyl； o, p, q are independently selected from 0 or 1 ； and x denotes an integer ranging from 1 to 10.3. The composition of claim 1, wherein the at least one benzoic acid or benzoic acid derivative is aminobenzoate, hydroxybenzoate, amino hydroxybenzoate, a derivative thereof, or a combination thereof. The composition of claim 3, wherein the aminobenzoate is selected from the group consisting of anthranilic acid, 3-aminobenzoic acid, 4,5-dimethylanthranilic acid, N-methylanthranilic acid, N-acetylanthranilic acid, phenamic acids (e.g., tolfenamic acid, mefenamic acid, flufenamic acid ), 2,4-diaminobenzoic acid (2,4-DABA), 2-acetylamino-4-aminobenzoic acid, 4-acetylamino-2-aminobenzoic acid, 2,4-diacetylaminobenzoic acid, their derivatives and their combinations. 5. The composition of claim 3, wherein the hydroxybenzoate is selected from the group consisting of salicylic acid, acetylsalicylic acid (aspirin), 3-hydroxybenzoic acid, 4-hydroxybenzoic acid, 6-methylsalicylic acid, o, m, p-cresotinic acid, anacardic acids, 4 5-dimethylsalicylic acid, o, m, p-hydroxy-p1. Композиция, содержащая по меньшей мере один конъюгат, при этом конъюгат содержит гидрокодон и по меньшей мере одну бензойную кислоту, ее производное, ее соль или их комбинацию.2. Композиция по п.1, где по меньшей мере одна бензойная кислота или производное бензойной
