4′-demethylepipodophyllotoxin derivative, preparation method and use thereof

• 收藏
• 分享

专利权人:

发明人:

Ya-Jie Tang,Wei Zhao

申请号：

US14036443

公开号：

US08796279B2

申请日:

2013.09.25

申请国别(地区):

US

年份:

2014

代理人:

摘要：

A 4′-demethylepipodophyllotoxin derivative of formula (III) having anti-tumor activity is provided. After the activation of hydroxyl in position C4 of 4′-demethylepipodophyllotoxin, tetramethylpyrazine is introduced by transamination to obtain the 4′-demethylepipodophyllotoxin derivative which is preferably used to inhibit gastric cancer line BGC-823.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/