4-DEMETHYLEPIPODOPHYLLOTOXIN DERIVATIVE, PREPARATION METHOD AND USE THEREOF

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专利权人:

YaJie Tang

发明人:

YaJie Tang

申请号：

US13641114

公开号：

US20130040967A1

申请日:

2011.04.22

申请国别(地区):

US

年份:

2013

代理人:

摘要：

A 4′-demethylepipodophyllotoxin derivative of formula(III) having anti-tumor activity is provided. After the activation of hydroxyl in position C4 of 4′-demethylepipodophyllotoxin, tetramethylpyrazine is introduced by transamination to obtain the 4′-demethylepipodophyllotoxin derivative which is preferably used to inhibit gastric cancer line BGC-823.

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