MEIER, CHRISTIAN,NOLLENBERGER, KATHRIN,GRYCZKE, ANDREAS,PETEREIT, HANS-ULRICH,DRESSMAN, JENNIFER
申请号：
EP07703962.6
公开号：
EP1978936B1
申请日:
2007.01.17
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The invention relates to a pharmaceutical composition comprising a mixture of at least one cationic, water-soluble (meth)acrylate copolymer, at least one water-insoluble polymer and at least one active ingredient having a solubility in demineralized water of 3.3 g/l or less, characterized in that the water-insoluble polymer and the active ingredient are present in a ratio of at most 3.5 to 1 parts by weight, and the pharmaceutical composition has the property of releasing the active ingredient present in a medium buffered to pH 1.2 in dissolved form in a concentration which, after 2 hours at pH 1.2, corresponds to at least sixteen times the solubility value of the active ingredient alone at pH 1.2.
