Pedro Alfonso,Michael Capaldi,Dennis Dong,Thomas R. Gervais,Joshua Goldstein,Allen B. Magill,Nicole Quinlan,Deepak Saini
申请号：
US11875243
公开号：
US08853371B2
申请日:
2007.10.19
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Methods useful for producing a solution of purified Fc peptide chains are disclosed. The methods employ protein A chromatography to separate high molecular weight, aggregated peptide chains comprising antibody Fc domains from lower molecular weight unaggregated peptide chains that also comprise antibody Fc domains. The solutions of purified Fc peptide chains obtained by the methods of the invention contain less than 5% aggregate and greater than 70% of the Fc peptide chains subjected to purification.
