ДЕКЕРТ Джутта (US),ПАРК Питер (US),ТАВАРЕС Дэниел (US),РУИ Линюнь (US)
申请号：
RU2012139045/10
公开号：
RU2012139045A
申请日:
2011.03.11
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. An antibody or antigen binding fragment of an antibody that specifically binds to CD37, characterized in that said antibody or antibody fragment is capable of inducing complement dependent cytotoxicity (SCC) .2. An antibody or antigen binding fragment thereof according to claim 1, characterized in that said antibody or antigen binding fragment thereof specifically binds to SEQ IDNO: 180.3 polypeptide. An antibody or antigen-binding antibody fragment according to claim 1, characterized in that said antibody or antibody fragment is capable of inducing in vitro apoptosis of cells expressing CD37 in the absence of cross-linking agents. An antibody or antigen-binding antibody fragment according to claim 1, characterized in that said antibody or antibody fragment is capable of inducing antibody-dependent cell cytotoxicity (ADCC). An antibody or antigen binding fragment of an antibody according to claim 1, characterized in that said antibody or antibody fragment binds to the same CD37 epitope as an antibody selected from the group consisting of: (a) an antibody comprising the polypeptide of SEQ ID NO: 55 and a polypeptide of SEQ ID NO: 72； (b) an antibody containing a polypeptide of SEQ ID NO: 59 and a polypeptide of SEQ ID NO: 75； (c) an antibody containing a polypeptide of SEQ ID NO: 61 and a polypeptide of SEQ ID NO: 77； (d) an antibody comprising a polypeptide of SEQ ID NO: 64 and a polypeptide of SEQ ID NO: 80； (e) an antibody comprising a polypeptide of SEQ ID NO: 66 and a polypeptide of SEQ ID NO: 82； (e) an antibody comprising the polypeptide of SEQ ID NO: 68 and the polypeptide of SEQ ID NO: 84； and (g) an antibody comprising the polypeptide of SEQ ID NO: 70 and the polypeptide of SEQ ID NO: 86, or competitively inhibit said antibody. An antibody or antigen binding fragment of an antibody according to claim 1, characterized in that said antibody or fragment1. Антитело или антигенсвязывающий фрагмент антитела, специфично связывающиеся с CD37, отличающиеся тем, ч
