РОТЕЛЛО Рокко Джейми (US),ПЕТЕРС Кевин Джин (US),ДЭВИС Майкл Глен (US)
申请号：
RU2011141686/10
公开号：
RU2011141686A
申请日:
2011.10.14
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. An isolated antibody or antigen binding fragment thereof capable of binding to the human tyrosine phosphatase beta protein (HPTP β), wherein said antibody or antigen binding fragment thereof regulates angiogenesis. The isolated antibody or antigen binding fragment thereof according to claim 1, characterized in that the antibody is capable of binding to the N-terminal portion of HPPβ.3. The isolated antibody or its antigen-binding fragment according to claim 2, characterized in that the antibody is capable of binding to the first FN3 repeat of HPTPβ. 4. The isolated antibody or antigen-binding fragment thereof according to claim 3, characterized in that the first FN3 repeat of HPTPβ comprises a sequence as shown in SEQ ID NO: 11, or a fragment thereof. The isolated antibody or antigen binding fragment thereof according to claim 1, characterized in that the antibody is a monoclonal antibody. The isolated antibody or antigen-binding fragment thereof according to claim 5, characterized in that the isolated antibody or its fragment is produced by ATCC hybridoma cell line No. PTA-7580.7. An isolated antibody or antigen binding fragment thereof according to claim 1, characterized in that the antibody or antigen binding fragment thereof is humanized. The isolated antibody or its antigen-binding fragment according to claim 6, characterized in that it contains the remains of the antigenic binding region from the monoclonal antibody R15E6 and is humanized. The isolated antibody or antigen binding fragment thereof according to claim 7, wherein the fragment includes the variable regions of the heavy and light chains. The isolated antibody or its antigen binding fragment according to claim 7, characterized in that the antigen binding fragment is selected from the group�1. Выделенное антитело или его антиген-связывающий фрагмент, способные связываться с человеческим белком тирозин фосфатазой бета (НРТРβ), при этом упомянутые антитело или его антиген-связывающий фрагмент регулир
