In one or a plurality of embodiments, there is provided a target molecule of amylospheroid, which is expressed in mature neurons and to which the amylospheroid binds to induce death of cells. Further, in one or a plurality of embodiments, there is provided a method and a substance for inhibiting death of mature neurons induced by the amylospheroid. In one aspect, the present disclosure relates to a use of Na+/K+-ATPase α3 as a binding target molecule of amylospheroid. In another aspect, the present disclosure relates to a method for suppressing death of mature neurons induced by the amylospheroid, including inhibiting protein-protein interaction between the amylospheroid and the Na+/K+-ATPase α3, and the like.本發明於一個或複數個實施形態中提供一種標靶分子，其係於成熟神經細胞中表現之澱粉球蛋白之標靶分子，且藉由與澱粉球蛋白結合而誘發細胞死亡。又，本發明於一個或複數個實施形態中提供一種抑制澱粉球蛋白所誘發之成熟神經細胞死亡的方法及物質。本發明於一態樣中係關於一種作為澱粉球蛋白之結合標靶分子之Na+/K+-ATP酶α3之用途。於其他態樣中，係關於一種抑制澱粉球蛋白所誘發之成熟神經細胞死亡的方法等，該方法包括阻礙澱粉球蛋白與Na+/K+-ATP酶α3之蛋白質間相互作用等。
