TENG, NELSON N. H.,田 尼尔森,田 尼爾森,BHAT, NEELIMA M.,巴特 里利马,巴特 里利馬,BIEBER, MARCIA M.,毕波 马西亚,畢波 馬西亞,KEYT, BRUCE A.,齐特 布鲁斯,齊特 布魯斯,田 尼尔森,田 尼爾森,巴特 里利马,巴特 里利馬,毕波 马西亚,畢波 馬西亞,齐特 布鲁斯,齊特 布魯斯
申请号：
TW102105337
公开号：
TW201345921A
申请日:
2013.02.08
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present disclosure relates to Cell Death Inducing Molecule (“CDIM”) binding proteins and pharmaceutical compositions thereof. Particularly, the disclosure provides CDIM binding proteins that are useful in the selective depleting and killing of B cells, including neoplastic B cells as well as neoplastic cells that are not of B-cell origin that express CDIM-like antigens. In addition, the disclosure encompasses polynucleotides encoding the disclosed antigen binding proteins, and expression systems for producing the same. Further the present disclosure encompasses methods of treating patients with B cell proliferative- and mediated diseases by administering the CDIM binding proteins as well as diagnostic assays for identifying proteins that bind to CDIM. The disclosure further contemplates diagnostic assays for identifying patient populations that can be treated with the CDIM binding proteins.本發明關於細胞死亡誘導分子(CDIM)結合蛋白及彼等之醫藥組成物。特別是，本發明提供可用於選擇性除盡及殺滅B細胞之CDIM結合蛋白，該等B細胞包括腫瘤性B細胞以及非B細胞來源之表現CDIM樣抗原之腫瘤樣細胞。此外，本發明包含編碼該經揭示之抗原結合蛋白之多核苷酸，以及用於產製該相同物之表現系統。本發明另包含藉由投予該CDIM結合蛋白以治療B細胞增生性及B細胞媒介性疾病病患之方法，以及用於識別與CDIM結合之蛋白質的診斷試驗。本發明另包含用於識別可以CDIM結合蛋白治療之病患族群的診斷試驗。
