The present application provides a class of cell necrosis inhibitors as well as preparation methods and uses thereof. Specifically, the present application provides an inhibitor for inhibiting cell necrosis and/or human receptor interacting protein 1 kinase (RIP1). The agent has the structure shown in Formula I below. The compound and the composition containing it can be used for preventing and/or treating diseases involving cell death and/or inflammation.本申請案提供一類細胞壞死抑制劑及其製備方法和用途，具體而言，本申請案提供一種抑制細胞壞死及/或人受體相互作用蛋白1激酶(RIP1)之抑制劑，所述之抑制劑具有如下式I所示之結構。該化合物及包含其之組合物可用於預防及/或治療涉及細胞死亡及/或發炎之疾病。
