OH, SANG HO,吴相昊,吳相昊,KIM, JONG GYUN,金锺均,金鍾均,OH, SE-WOONG,吴世雄,吳世雄,HAN, TAE DONG,韩兑东,韓兌東,CHUNG, SOO YONG,郑水龙,鄭水龍,LEE, SEONG RAN,李性兰,李性蘭,KIM, KYEONG BAE,金京培,LEE, YOUNG SUNG,李永成,SHIN, WOO SEOB,申优燮
申请号：
TW107113234
公开号：
TW201841910A
申请日:
2018.04.18
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
The present invention relates to novel mesylate salt of N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide, a novel crystalline form thereof, and a process for preparing the same. More specifically, the present invention relates to mesylate salt of N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide, which is excellent in stability, solubility, and bioavailability when it is administered not only alone but also in combination with other drugs and which has a high purity, a crystalline form thereof, and a process for preparing the same.本發明係有關N-(5-(4-(4-((二甲基胺基)甲基)-3-苯基-1H-吡唑-1-基)嘧啶-2-基胺基)-4-甲氧基-2-嗎啉基苯基)丙烯醯胺、其新穎結晶形、及其製備方法。更明確地說，本發明係有關N-(5-(4-(4-((二甲基胺基)甲基)-3-苯基-1H-吡唑-1-基)嘧啶-2-基胺基)-4-甲氧基-2-嗎啉基苯基)丙烯醯胺的甲磺酸鹽，當該甲磺酸鹽不只單獨投予且亦與其他藥物合併投予時，其在穩定性、溶解度、和生體可用率係極為優異且其具有高純度；其結晶形、及其製備方法。
