Dean D. Schwartz,Christian R. Goldsmith,Ronald J. Beyers,Meng Yu
申请号：
US15230030
公开号：
US10233205B2
申请日:
2016.05.08
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The current invention provides metal ion complexes with an organic ligand, compositions comprising such complexes. In particular, these complexes are capable of reacting with a reactive oxygen species in a subject and increase their T1-weighted relaxivities so a clinical MRI scanner can detect an oxidative stress hotspot in the subject. The disclosed complexes also exhibit excellent anti-oxidant properties and low cell toxicity, therefore can be used as a therapeutic agent to relieve oxidative stress in the subject, or as both a MRI contrast agent and therapeutic agent in a composition.
