INSTITUTE OF MATARIA MEDICA; CHINESE ACADEMY OF MEDICAL SCIENCES
发明人:
LIU, GANG,ZHAO, NAN,MA, YAO
申请号：
EP11786102
公开号：
EP2612857A4
申请日:
2011.05.27
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present invention discloses chemical synthesis, anti-tumor and anti-metastatic effects of a dual functional conjugate as showed by formula I. In detail, paclitaxel or docetaxol is linked with muramyl dipeptide derivative to form a conjugate, thus dual anti-tumor and anti-metastatic effects are achieved by combination of chemotherapy and immunotherapy. The present invention also discloses that paclitaxel or docetaxol and muramyl dipeptide derivative conjugate is synthesized by combination of solid-phase and solution-phase synthesis, and said conjugate can be used in manufacture of anti-tumor medicaments as proved by reliable bioassays.
