PROBLEM TO BE SOLVED: To provide a novel benzoisofranone derivative as a medicine which acts on a response by gamma interferon between an epithelial cell and a stroma cell to induce the repair and regeneration of an internal organ tissue after the tissue concerned is damaged to provide a novel benzoisofranone derivative as a medicine which acts on a response by lymphotoxin alpha between an epithelial cell and a stroma cell to induce the repair and regeneration of an internal organ tissue after the tissue concerned is damaged and to provide a novel benzoisofranone derivative as a medicine which modifies a responsive reaction in a process, in which a cell is damaged by TGF-beta 1, to induce the repair and regeneration of an internal organ tissue after the tissue concerned is damaged.SOLUTION: The novel benzoisofranone derivative, which has the action to modify a process in which a cell is damaged, is a medicine for repairing, regenerating and treating an internal organ tissue. The novel benzoisofranone derivative which has the action to modify a process in which a cell is damaged, together with a macrophage or a tissue-effector cell, is a medicine for repairing, regenerating and treating an internal organ tissue.COPYRIGHT: (C)2012,JPO&INPIT【課題】新規ベンゾイソフラノン誘導体がガンマーインターフェロンによる上皮系・間質系細胞間応答に作用することによって臓器組織傷害後の修復再生を誘導する医薬を提供する。あるいは、新規ベンゾイソフラノン誘導体がリンフォトキシンアルファによる上皮系・間質系細胞間応答に作用することによって臓器組織傷害後の修復再生を誘導する医薬を提供する。さらに、新規ベンゾイソフラノン誘導体がTGF-ベータ1による障害をうけた細胞の損傷過程の応答反応を修飾することにより臓器組織傷害後の修復再生を誘導する医薬を提供する。【解決手段】傷害をうけた細胞の損傷過程を修飾する作用を有する臓器組織の修復再生治療薬。【選択図】なし
