The fluoridated hydroxyapatite composites having an action of enhancing the biological activity of human osteoblast cells, a process for the preparation thereof, and a pharmaceutical composition comprising them.
Fluoridated hydroxyapatite composites have both the OH and the OH.F hydrogen bonds or both the OH.F and OH.F.HO hydrogen bonds of different FT-IR function group performance. Fluoridated hydroxyapatite composites of this invention or their constituents of the other compounds do as bone filler, they may promote osteogenesis and regeneration of the hard tissue. Constituents of this invention may further contain one kind or many kinds of osteogenetic and regenerative medical constituents, cause this medical constituents further be helpful to bone tissue osteogenesis and regeneration when implant into animal hard tissue defect.氟化羥磷灰石複合物經傅立葉轉換紅外線光譜儀檢測同時具有羥基團(OH)與羥基氟離子氫鍵(OH.F)或同時具有羥基團(OH)與不同羥基氟離子氫鍵(OH.F和OH.F.HO)等各種不同官能基表現,且具有提昇人類造骨細胞生物活性作用之氟化羥磷灰石複合物,其製備方法及包含這些複合物之醫藥組成。本發明之氟化羥磷灰石複合物或其與其他化合物之組成物適用做為骨骼填充劑,其可以促進骨細胞之再生與修復。又,本發明之組成物可進一步包含有一種或多種骨再生與修復的醫藥組成物,以使該醫藥組成物被植入動物體內進一步有助於體內骨組織再生與修復。圖5.顯示氟化羥磷灰石複合物於不同條件製備下,傅立葉轉換紅外光譜儀檢測結果,分別具備(a) OH和OH.F氫鍵;或(b) OH,OH.F和OH.F.HO氫鍵,各種不同官能基表現者。(*,OH鍵;+,OH.F鍵;#,OH.F.HO鍵)
