ILLIG, Carl R.,BALLENTINE, Shelley K.,CHEN, Jinsheng,MEEGALLA, Sanath,RUDOLPH, M. Jonathan,WALL, Mark J.,WILSON, Ken,DESJARLAIS, Renee,MOLLOY, Christopher,MANTHEY, Carl,FLORES, Christopher
申请号：
ES05815361
公开号：
ES2611604T3
申请日:
2005.10.20
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compound of Formula I: ** Formula ** or pharmaceutically acceptable solvate, hydrate, tautomer or salt thereof, in which: A is phenyl which may be substituted with one of chlorine, fluoro or methyl； W is pyrrolyl, imidazolyl, isoxazolyl, oxazolyl or furanyl, any of which may be connected through any carbon atom, in which the pyrrolyl, imidazolyl, isoxazolyl, oxazolyl or furanyl may contain a substitution -Cl, -CN, -NO2, -OMe or -CF3, connected to any other carbon； R2 is cycloalkyl, thiophenyl, dihydrosulfonopyranyl, phenyl, furanyl, tetrahydropyridyl or dihydropyranyl, any of which may be independently substituted with one or two of each of the following: chlorine, fluoro and C (1-3) alkyl, provided that tetrahydropyridyl is connected to ring A through a carbon carbon bond； wherein the term "cycloalkyl" refers to a saturated or partially unsaturated ring composed of 3 to 8 carbon atoms； X is ** Formula ** and is attached to the phenyl ring A in position with respect to the nitrogen substituent, as depicted in Formula II: ** Formula ** Z is CH or N； each of D1 and D2 is hydrogen, or together they form a double bond to an oxygen； D3 and D4 are hydrogen； E is N or SO2, provided that E is not N if the following three conditions are met at the same time: Qa is absent, Qb is absent, and R3 is an amino group or a cyclic amino radical in which the point of fixation to E is N； Qa is absent, it is -CH2-, -CH2CH2-, or -C (O) -； Qb is absent, it is -NH-, -CH2-, -CH2CH2- or -C (O) -, provided that Qb is not C (O) if Qa is C (O), and provided that Qb also is not -NH- if E is N and Qa is absent, provided that in addition Qb is not -NH- if R3 is an amino group or a cyclic amino radical in which the point of attachment to Qb is N； R3 is hydrogen, piperidinyl, alkylamino, dialkylamino, hydroxyalkylamino, (hydroxyalkyl) 2amino, imidazolyl, 1- methyl imidazolyl, pyridyl, pyridyl N-oxide, hydroxyalkyl, -COOH, -CONH2, -CN, -SO2CH3, -NH2, morpholinyl ； R3 may also be absent, provided that
