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PHYSICALLY AND CHEMICALLY STABLE ORAL SUSPENSIONS OF GIVINOSTAT
专利权人:
ITALFARMACO SPA
发明人:
Giuseppe COLOMBO,Roberta ARTICO,Paolo MASCAGNI,Maria Valmen MONZANI,Silvia PUCCIANTI
申请号:
US15770443
公开号:
US20180311160A1
申请日:
2016.10.28
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Physically and chemically stable oral liquid formulations of Givinostat (Diethyl-[6-(4-hydroxycarbamoyl-phenylcarbamoyloxymethyl)-naphthalen-2-yl-methyl]-ammonium chloride) are disclosed, together with methods for the preparation thereof. Such oral formulations are in the form of aqueous suspensions and contain Givinostat and/or pharmaceutically acceptable salts and/or derivatives thereof, at least a wetting agent and/or at least a density-imparting agent. Such formulations are suitable for oral administration for systemic therapeutic action.
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