ANDREA BEST,DUNCAN CASSON,JERRY A. HALL,JOHN POWELL,MARK MAGINN,SANDEEP DUTTA,WEI LIU
申请号：
BRPI1014445
公开号：
BRPI1014445A2
申请日:
2010.05.04
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
