Sandeep Dutta;Wei Liu;Andrea Best;Duncan Casson;Jerry A. Hall;Mark Maginn;John Powell
发明人:
John Powell,Duncan Casson,Mark Maginn,Wei Liu,Sandeep Dutta,Andrea Best,Jerry A. Hall
申请号：
US12773488
公开号：
US08435523B2
申请日:
2010.05.04
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
