DUNCAN CASSON;ABBOTT RESEARCH B.V.;MARK MAGINN;JOHN POWELL
发明人:
JOHN POWELL,MARK MAGINN,DUNCAN CASSON
申请号：
IL21612811
公开号：
IL216128A
申请日:
2011.11.03
申请国别(地区):
IL
年份:
2015
代理人:
摘要：
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
