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Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
- 专利权人:
- ABBVIE INC.
- 发明人:
- DING, HONG,ELMORE, STEVEN,HEXAMER, LAURA,KUNZER, AARON,PARK, CHEOL-MIN,SOUERS, ANDREW,SULLIVAN, GERARD,WENDT, MICHAEL
- 申请号：
- ES11709579
- 公开号：
- ES2553143T3
- 申请日:
- 2011.03.10
- 申请国别(地区):
- ES
- 年份:
- 2015
- 代理人:
- 摘要：
- A compound, or a therapeutically acceptable salt thereof, wherein the compound is selected from the group consisting of: 4- (4- {acetyl [(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3 , 1,1] hept-3-yl] amino} piperidin-1-yl) -N - ({4- [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) benzamide； 4- (4- {benzyl [(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3,1,1] hept-3-yl] amino} piperidin-1-yl) -N- ( {4- [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) benzamide； N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) -3 '- {[(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3,1,1] hept -3-yl] amino} biphenyl-4-carboxamide； N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) -4- (4 - {(phenylacetyl) [(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3, 1,1] hept-3-yl] amino} piperidin-1-yl) benzamide； N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) -4 '- {[(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3,1,1] hept -3-yl] amino} biphenyl-4-carboxamide； N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) -4 '- {(3-phenylpropyl) [(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3, 1,1] hept-3-yl] amino} biphenyl-4-carboxamide； 4- (4 - {[(1R, 5R) -3-bromo-5-methylamantan-1-yl] methyl} piperazin-1-yl) -N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl } sulfonyl) benzamide； N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) -4- (4 - {[3,5-dimethylamantan-1-yl] methyl} piperazin-1- yl) benzamide； N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) -4- (4- {2 - [(1R, 4R) -1,7,7- trimethylbicyclo [2,2,1] hept-2-en-2-yl] benzyl} piperazin-1-yl) benzamide； N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) -4- (4- {2-octahydro-1H-4,7-methanoinden-5- ylamino ] benzyl} piperazin-1-yl) benzamide； N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) -4- [4- (2 - {[(1R, 4R, 6S) -5.5 , 6- trimethylbicyclo [2,2,1] hept-2-yl] amino} benzyl) piperazin-1-yl] benzamide； 4- [4- (2 -
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
